DelveInsight’s “Bladder Cancer Pipeline Insight 2026” report provides comprehensive insights about 80+ companies and 100+ pipeline drugs in the Bladder cancer pipeline landscape. It covers the Bladder Cancer pipeline drug profiles, including clinical and nonclinical stage products. It also covers the Bladder Cancer pipeline therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

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Key Takeaways from the Bladder Cancer Pipeline Report

• On June 25, 2026- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins initiated a Phase II trial involving the use of atezolizumab plus platinum and etoposide for patients with locally advanced urothelial cancer. The primary goal of this trial is to assess the pathologic complete response rate at cystectomy in patients after being treated with a combination therapy of atezolizumab, platinum, and etoposide.
• On June 23, 2026- Fidia Farmaceutici s.p.a. conducted a phase III, single-arm, multicenter, international study to assess the efficacy and safety of ONCOFID-P-B following intravesical instillation in adult patients with histologically and cytologically confirmed CIS, with or without concomitant Ta-T1, who are unresponsive to BCG therapy and unwilling or unfit to undergo radical cystectomy.
• On June 23, 2026- Merck Sharp & Dohme LLC announced a Phase 1/2 Study of Intravesical MK-3120 in BCG-Naïve or BCG-Exposed High-Risk Non-muscle Invasive Bladder Cancer. In standard treatment for HR NMIBC, doctors first remove the tumor with a procedure called transurethral resection of the bladder tumor (TURBT). Researchers want to learn if using MK-3120, the study medicine, can treat HR NMIBC after TURBT. The goal of this study is to learn about the safety of MK-3120 and if people tolerate it.
• On June 23, 2026- Janssen Research & Development LLC conducted a phase 2 study is to evaluate the anti-tumor effects of TAR-200 in combination with intravenous (IV) cetrelimab and IV cetrelimab alone.
• On June 08, 2026- Astellas Pharma Global Development Inc. initiated a phase 3 study is being done to see how well two drugs (enfortumab vedotin and pembrolizumab) work together as a bladder preservation approach to treat patients with muscle invasive bladder cancer. The study will compare these drugs to concurrent chemoradiotherapy that is usually used to treat this cancer (standard of care). The study will enroll patients with muscle-invasive bladder cancer (MIBC) who have cancer that has not spread outside the bladder.
• DelveInsight’s Bladder Cancer pipeline report depicts a robust space with 80+ active players working to develop 100+ pipeline therapies for Bladder Cancer treatment.
• The leading Bladder Cancer Companies such as CG Oncology, Inc., Johnson & Johnson, Eli Lilly and Company, Relmada Therapeutics, Inc., Protara Therapeutics, Theralase® Technologies Inc., Tyra Biosciences, Inc., Bristol-Myers Squibb, Merck & Co., Inc., Molecular Partners AG, Aura Biosciences, BioNTech SE, Tasca Therapeutics, Iambic Therapeutics, Inc., Monopar Therapeutics, Pilatus Biosciences Inc., Second Life Therapeutics, SURGE Therapeutics and others.
• Promising Bladder Cancer Therapies such as Atezolizumab, PGV001, VAX014, BCG Vaccine, Oncofid-P-B, Oncofid-P-B, and others.

Stay informed about the cutting-edge advancements in Bladder Cancer Treatments @ Bladder Cancer Clinical Trials Assessment

Bladder Cancer Overview

Bladder cancer is a malignant condition in which abnormal cells grow uncontrollably in the tissues of the urinary bladder, most commonly in the urothelial cells lining the inside of the bladder. Urothelial carcinoma (transitional cell carcinoma) is the most common type, accounting for the majority of bladder cancer cases. The disease may remain confined to the bladder lining (non–muscle-invasive bladder cancer) or invade deeper muscle layers and spread to other organs (muscle-invasive or metastatic bladder cancer). Common symptoms include blood in the urine (hematuria), painful urination, urinary urgency, and pelvic pain.

Bladder cancer Emerging Drugs Profile

• Cretostimogene grenadenorepvec: CG Oncology

Cretostimogene grenadenorepvec is an investigational intravesically delivered oncolytic immunotherapy developed by CG Oncology for bladder cancer. The drug is a genetically engineered adenovirus designed to selectively replicate in and destroy retinoblastoma pathway–defective bladder tumor cells while simultaneously stimulating anti-tumor immune responses through granulocyte-macrophage colony-stimulating factor (GM-CSF) expression. Its mechanism of action involves direct oncolysis of tumor cells combined with activation of local and systemic immune-mediated anti-cancer activity. The U.S. FDA has granted both Fast Track Designation and Breakthrough Therapy Designation to cretostimogene grenadenorepvec for high-risk BCG-unresponsive NMIBC. Currently, the drug is being evaluated in the Phase III stage of its development for the treatment of Bladder Cancer.

• Erda-iDRS: Johnson & Johnson

Erda-iDRS is an investigational intravesical drug-releasing system, the therapy is designed to provide prolonged local delivery of erdafitinib, a fibroblast growth factor receptor (FGFR) kinase inhibitor, directly into the bladder over an extended period. Its mechanism of action in bladder cancer involves selective inhibition of FGFR alterations, which are commonly associated with tumor growth and recurrence in non–muscle-invasive bladder cancer (NMIBC), while minimizing systemic exposure through localized intravesical administration. Currently, the drug is being evaluated in the Phase III stage of its development for the treatment of Bladder Cancer.

• MK-1022: Merck & Co.

MK-1022 is an investigational antibody-drug conjugate (ADC) being developed by Merck & Co. The drug consists of a fully human anti-HER3 IgG1 monoclonal antibody linked to a topoisomerase I inhibitor payload. Its mechanism of action in bladder cancer involves targeting HER3-expressing tumor cells, followed by internalization of the ADC and intracellular release of the cytotoxic topoisomerase I inhibitor, resulting in DNA damage and tumor cell death. Currently, the drug is being evaluated in the Phase II stage of its development for the treatment of Bladder Cancer.

• STM-416: SURGE

STM-416 is an investigational intraoperative immunotherapy for the treatment of recurrent high-grade non-muscle-invasive bladder cancer (NMIBC). The drug is a biodegradable hydrogel formulation containing resiquimod, a Toll-like receptor 7/8 (TLR7/8) agonist, designed for sustained local release at the tumor resection site following transurethral resection of bladder tumor (TURBT). STM-416 works by activating innate and adaptive immune responses through TLR7/8 signaling, thereby promoting anti-tumor activity and helping prevent bladder cancer recurrence and progression after surgery. Currently, the drug is being evaluated in the Phase I/II stage of its development for the treatment of Bladder Cancer.

• SL-28: Second Life Therapeutics

SL-28 is an investigational allogeneic, non-genetically modified cell therapy being developed by Second Life Therapeutics for advanced solid tumors, including bladder cancer. The mechanism of action of SL-28 involves TezR-modified donor leukocytes engineered through modulation of the Universal Receptive System and Cell Memory, which activates multiple anticancer pathways including immune cell signaling, migration, endocytosis, phagocytosis, and energy metabolism to promote tumor destruction. In bladder cancer, SL-28 is intended to target resistant genitourinary tumors through enhanced immune-mediated anticancer activity. Currently, the drug is being evaluated in the Phase I/II stage of its development for the treatment of Bladder Cancer.

• IAM1363: Iambic Therapeutics, Inc.

IAM1363 is an investigational small-molecule, brain-penetrant HER2 tyrosine kinase inhibitor. The drug is designed to selectively inhibit both wild-type and oncogenic mutant HER2 proteins while sparing EGFR, thereby reducing EGFR-related toxicities commonly associated with pan-ERBB inhibitors. In bladder cancer, IAM1363 targets HER2-driven tumor signaling pathways that promote cancer cell proliferation, survival, and metastasis. Currently, the drug is being evaluated in the Phase I stage of its development for the treatment of Bladder Cancer.

The Bladder Cancer Pipeline report provides insights into

• The report provides detailed insights about companies that are developing therapies for the treatment of Bladder Cancer with aggregate therapies developed by each company for the same.
• It accesses the Different therapeutic candidates segmented into early-stage, mid-stage, and late-stage of development for Bladder Cancer Treatment.
• Bladder Cancer Companies are involved in targeted therapeutics development with respective active and inactive (dormant or discontinued) projects.
• Bladder Cancer Drugs under development based on the stage of development, route of administration, target receptor, monotherapy or combination therapy, a different mechanism of action, and molecular type.
• Detailed analysis of collaborations (company-company collaborations and company-academia collaborations), licensing agreement and financing details for future advancement of the Bladder Cancer market.

Learn more about Bladder Cancer Drugs opportunities in our groundbreaking Research and development projects @ Bladder Cancer Unmet Needs

Bladder Cancer Companies

CG Oncology, Inc., Johnson & Johnson, Eli Lilly and Company, Relmada Therapeutics, Inc., Protara Therapeutics, Theralase® Technologies Inc., Tyra Biosciences, Inc., Bristol-Myers Squibb, Merck & Co., Inc., Molecular Partners AG, Aura Biosciences, BioNTech SE, Tasca Therapeutics, Iambic Therapeutics, Inc., Monopar Therapeutics, Pilatus Biosciences Inc., Second Life Therapeutics, SURGE Therapeutics and others.

Bladder cancer pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration

• Intra-articular
• Intraocular
• Intrathecal
• Intravenous
• Ophthalmic
• Oral
• Parenteral
• Subcutaneous
• Topical
• Transdermal

Bladder Cancer Products have been categorized under various Molecule types such as

• Oligonucleotide
• Peptide
• Small molecule

Discover the latest advancements in Bladder Cancer Treatment by visiting our website @ Bladder Cancer Market Drivers and Barriers, and Future Perspectives

Scope of the Bladder Cancer Pipeline Report

• Coverage- Global
• Bladder Cancer Therapeutic Assessment by Product Type: Mono, Combination, Mono/Combination
• Bladder Cancer Therapeutic Assessment by Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III
• Bladder Cancer Companies- CG Oncology, Inc., Johnson & Johnson, Eli Lilly and Company, Relmada Therapeutics, Inc., Protara Therapeutics, Theralase® Technologies Inc., Tyra Biosciences, Inc., Bristol-Myers Squibb, Merck & Co., Inc., Molecular Partners AG, Aura Biosciences, BioNTech SE, Tasca Therapeutics, Iambic Therapeutics, Inc., Monopar Therapeutics, Pilatus Biosciences Inc., Second Life Therapeutics, SURGE Therapeutics and others.
• Bladder Cancer Therapies- Atezolizumab, PGV001, VAX014, BCG Vaccine, Oncofid-P-B, Oncofid-P-B, and others.

Read the full details of Bladder Cancer Pipeline on our website @ Bladder Cancer Drugs and Companies

Table of Content

1. Introduction
2. Bladder Cancer Executive Summary
3. Bladder Cancer: Overview
4. Bladder Cancer Pipeline Therapeutics
5. Bladder Cancer Pipeline Therapeutic Assessment
6. Late Stage Products (Phase III)
7. Cretostimogene grenadenorepvec: CG Oncology
8. Drug profiles in the detailed report…..
9. Mid Stage Products (Phase II)
10. MK-1022: Merck & Co.
11. Early Stage Products (Phase I)
12. IAM1363: Iambic Therapeutics, Inc
13. Inactive Products
14. Bladder Cancer Key Companies
15. Bladder Cancer Key Products
16. Bladder Cancer – Unmet Needs
17. Bladder Cancer – Market Drivers and Barriers
18. Bladder Cancer – Future Perspectives and Conclusion
19. Bladder Cancer Analyst Views
20. Bladder Cancer Key Companies
21. Appendix

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