DelveInsight’s, “Gastroparesis Pipeline Insight, 2025” report provides comprehensive insights about 8+ companies and 10+ pipeline drugs in Gastroparesis pipeline landscape. It covers the Gastroparesis pipeline drug profiles, including clinical and nonclinical stage products. It also covers the Gastroparesis pipeline therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
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Key Takeaways from the Gastroparesis Pipeline Report
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Gastroparesis Emerging Drugs Profile
NG101 is an oral, small molecule peripherally acting dopamine D2 receptor antagonist. D2 receptor antagonists are an established class of therapeutics with demonstrated efficacy in relieving gastroparesis symptoms; however, their use has been limited because they are associated with an increased risk of serious CNS and cardiac side effects. NG101 is a proprietary mesylate salt form of metopimazine, a D2 receptor antagonist that has not been associated with an increased risk of serious CNS or cardiac side effects. Metopimazine has been approved and prescribed in France for over 40 years for the symptomatic treatment of nausea and vomiting and has been shown to be safe and generally well-tolerated for those indications. Currently, the drug is in Phase II stage of its development for the treatment of Gastroparesis.
CIN-102 (Deudomperidone) is a novel formulation of a well-known dopamine D2/D3 antagonist. Deudomperidone was designed to improve safety while maintaining the efficacy of domperidone, which has both prokinetic and antiemetic effects with no anticholinergic activity. Deudomperidone is a new chemical entity based upon deuteration and novel formulation of domperidone, a frequently prescribed first-line therapy for nausea, vomiting and gastroparesis outside of the US In part due to safety concerns around QT prolongation, domperidone is not approved in the US. Deudomperidone has been engineered to alter the PK profile for sustained efficacy while significantly reducing cardiac liability. Multiple clinical trials of deudomperidone demonstrated it was well tolerated, including no sponsor-assessed drug related adverse events (AEs) or clinically meaningful laboratory abnormalities. Deudomperidone was deemed to have no meaningful impact on QT at exposures well above a therapeutic dose in a thorough QT study and demonstrated target engagement and improvement in gastric emptying time in a previous clinical trial. Currently, the drug is in Phase II stage of its development for the treatment of Gastroparesis.
Capeserod is a selective 5-HT4 receptor partial agonist, which is being repurposed and developed for multiple GI conditions. Based on the biological evidence of expression of 5-HT4b receptor subtype in human GI tract, capeserod may directly or indirectly initiate the peristaltic or secretory reflex by releasing neurotransmitters that can decrease colonic transit time and improve bowel movement. Currently, the drug is in Phase I stage of its development for the treatment of Gastroparesis.
The Gastroparesis Pipeline Report Provides Insights into
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Gastroparesis Companies
Neurogastrx Inc., Dr. Falk Pharma GmbH, CinDome Pharma Inc., Entero Therapeutics Inc., RaQualia Pharma and others.
Gastroparesis pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as
Gastroparesis Products have been categorized under various Molecule types such as
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Scope of the Gastroparesis Pipeline Report
Which companies are leading the race in Gastroparesis drug development? Find out in DelveInsight’s exclusive Gastroparesis Pipeline Report—access it now! @ Gastroparesis Emerging Drugs and Major Companies
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